解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIM:To assess and compare the roles of plasma and urine concentrations of neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C for early diagnosis of septic acute kidney injury (AKI) in adult critically ill patients. METHODS:Patients were divided into three groups as sepsis-non AKI, sepsis-AKI and non seps...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130966
更新日期:2013-01-01 00:00:00
abstract::The role of human papillomavirus (HPV) in prostate carcinogenesis is highly controversial: some studies suggest a positive association between HPV infection and an increased risk of prostate cancer (PCa), whereas others do not reveal any correlation. In this study, we investigated the prognostic impact of HPV infectio...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/735843
更新日期:2013-01-01 00:00:00
abstract:AIM:To determine the implication of the polymorphism, namely, A(TA)nTAA of UGT1A1 in lithogenesis for the first time in Tunisia among sickle cell anemia (SCA) children patients. MATERIAL AND METHODS:Our study was performed in 2010 and it involved 76 subjects chosen as control group characterized with normal hemoglobin...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/173474
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Tumor cells show alterations in their glycosylation patterns when compared to normal cells. Lectins can be used to evaluate these glycocode changes. Chemiluminescence assay is an effective technique for quantitative analysis of proteins, nucleic acids, and carbohydrates due to its high sensitivity, specifici...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/787130
更新日期:2013-01-01 00:00:00
abstract::Immunization with a pandemic influenza A H1N1 2009 was recommended for HIV-infected patients. However, there is limited information concerning the impact of immunization with this vaccine on immune activation and HIV viral replication. In this study, 45 HIV-infected children and adolescents receiving antiretroviral th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/276547
更新日期:2013-01-01 00:00:00
abstract::Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its role in human cancers. To investigate the clinical significance of serum anti-CCNY autoantibodies in nonsmall-cell lung carcinoma (NSCLC), the serum levels of CCNY protein in 264 patients with NSCLC, 103 patients with tuberculosis, and 89 healthy ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/935943
更新日期:2013-01-01 00:00:00
abstract::Cytoskeletal rearrangement occurs in variety of cellular processes and involves a wide spectrum of proteins. Gelsolin super family proteins control actin organization by severing and capping filament ends and nucleating actin assembly. Gelsolin is the founding member of this family and plays important role in pathogen...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-120952
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE:We investigate if singl...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130991
更新日期:2013-01-01 00:00:00
abstract::In an attempt to better unfold the antitumor immune response and invasion strategies perused by tumor cells, markers such as CD99 and HLA-II have been stained in breast tumors, some of them turned out to be important for prognosis and its outcome. CD99 is involved in the intracellular transport of HLA-II proteins. The...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130982
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Cardiac troponin levels have been reported to add value in the detection of cardiovascular complications in noncardiac surgery. A sensitive cardiac troponin I (cTnI) assay could provide more accurate prognostic information. METHODS:This study prospectively enrolled 142 patients with at least one Revised Car...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/169356
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:The clinical behavior of unicystic ameloblastoma varies according to its subtype. The assessment of its proliferative capacity, neovascularization, and invasiveness using relevant immunomarkers may aid in appropriate surgical therapeutic protocol. METHODS:18 cases of clinically and histologically confirmed uni...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/517834
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:High serum MBL level as well as polymorphisms in the mannose-binding lectin 2 (MBL2) gene resulting in MBL deficiency are involved in the mechanism of a number of non-infectious diseases such as asthma, conferring either risk or protection in different population studies. MBL being the first reactant of the ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0892
更新日期:2012-01-01 00:00:00
abstract:AIM:In this study, we aimed to investigate the relationship between the histological fibrosis stage of nonalcoholic fatty liver disease (NAFLD) and serum connective tissue growth factor (CTGF) to determine the usefulness of this relationship in clinical practice. METHODS:Serum samples were collected from 51 patients w...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0907
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. METHODS:Expression profiles of IL-17, IL-23, and TGF-...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-00933
更新日期:2012-01-01 00:00:00
abstract::The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n=271) with a mean clinical follow-up time of 48 months were immunostained using th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0896
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Cystic fibrosis is a monogenic recessive disorder found predominantly in Caucasian population. This disease arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In this study we consider poly T polymorphism c.1210-12T[5], c.1210-12T[7], c.1210-12T[9] (T{5}, T{7}, T{9}...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0880
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC). METHODS:98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-00935
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Particularly interesting new cysteine-histidine rich protein (PINCH) is an important component of the local adhesion complexes and upregulated in several types of malignancies, and involved in the incidence and development of tumours. PINCH expression is also independently correlated with poorer survival in p...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0930
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Left ventricular dysfunction (LVD), followed by fall in cardiac output is one of the major complications in some coronary artery disease (CAD) patients. The decreased cardiac output over time leads to activation of the renin-angiotensin-aldosterone system which results in vasoconstriction by influencing salt...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0858
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. METHODS:We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patien...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2012/842764
更新日期:2012-01-01 00:00:00
abstract::Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate the influence of 12 genetic polymorphisms involved in folate metabolism on maternal risk for DS. In addition, we evaluated the impact of these polymorphisms on se...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0869
更新日期:2012-01-01 00:00:00
abstract::A multitude of host genetic factors plays a crucial role in susceptibility to HIV-1 infection and progression to AIDS, which is highly variable among individuals and populations. This review focuses on the chemokine-receptor and chemokine genes, which were extensively studied because of their role as HIV co-receptor o...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2011-0874
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Autism is among the commonest neurodevelopmental childhood disorders worldwide; its aetiology is still unknown. Iron metabolism alteration in the central nervous system is recently implicated as a risk factor for several neurodegenerative disorders. Haemochromatosis HFE gene polymorphisms (p.H63D and p.C282Y...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0830
更新日期:2011-01-01 00:00:00
abstract::Exhaled breath condensate (EBC) has been increasingly used as a new and non-invasive method to study airway inflammation. In this study we have compared the concentrations of lipid mediators in EBC with concentrations in bronchoalveolar lavage fluid (BALF). We included 37 patients undergoing bronchoscopy (12 sarcoidos...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0776
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Abdominal aortic aneurysms (AAAs) are characterized by presence of high proteolytic activity, atherosclerotic lesions, extensive transmural inflammation and the presence of variably sized and shaped intraluminal thrombus (ILT). Therefore, we evaluated a possible association between plasma matrix metalloprote...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0799
更新日期:2011-01-01 00:00:00
abstract::Nonenzymatic glycosylation or glycation of macromolecules, especially proteins leading to their oxidation, play an important role in diseases. Glycation of proteins primarily results in the formation of an early stage and stable Amadori-lysine product which undergo further irreversible chemical reactions to form advan...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2011-0791
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Genetics of non-alcoholic fatty liver (NAFLD) in Asian Indians has been inadequately investigated. This study aims to determine the association of the 1784G>C polymorphism in the SREBP-2 gene with NAFLD in Asian Indians in north India. METHODS:In this study, (n=335); 162 obese with NAFLD, 91 obese without N...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0852
更新日期:2011-01-01 00:00:00
abstract::Prognostic markers of compensated cirrhosis should mainly investigate factors involved with progression to decompensation because death in cirrhosis is related with decompensation. Portal hypertension plays a crucial role in the pathophysiology of most complications of cirrhosis. Accordingly, HVPG monitoring has stron...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2011-0837
更新日期:2011-01-01 00:00:00
abstract::Over the last two decades, significant data has been accumulated linking Glutatione S-Transferases (GSTs) with the development of several diseases. Contemporary studies have demonstrated the impact of ethnicity on GST allele frequencies. The aim is to verify if the variability of GST genes reflects population demograp...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0821
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether single nucleotide polymorphisms (SNPs) in the Mn-superoxide dismutase gene (SOD2) underlie the susceptibility to noise-induced hearing loss (NIHL). METHODS:Audiometric data from 2400 Chinese Han workers who exposed to occupational noise were analyzed. DNA samples were collected from th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0693
更新日期:2010-01-01 00:00:00
abstract::The recent advances in high-throughput data acquisition have driven a revolution in the study of human disease and determination of molecular biomarkers of disease states. It has become increasingly clear that many of the most important human diseases arise as the result of a complex interplay between several factors ...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2010-0695
更新日期:2010-01-01 00:00:00
abstract::The role of pro-fibrogenic cytokines in the outcome of infections with hepatitis C virus (HCV) and the response to treatment with pegylated interferon-alpha (pegIFNalpha) and ribavirin remains unclear. To address this issue, we assessed hepatic fibrosis and plasma markers pertinent to T-cell mediated fibrogenesis and ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0699
更新日期:2010-01-01 00:00:00
abstract::Lung disease due to non-tuberculous mycobacteria (NTM) is a poorly understood condition that is difficult to treat. Treatment remains problematic as few tools are available to help clinicians monitor disease progression or predict treatment outcome. In this study, plasma levels of several inflammatory molecules and th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0732
更新日期:2010-01-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology, characterized by injury of the intrahepatic bile ducts that may eventually lead to cirrhosis and liver failure. Evidence suggests cardinal roles for both environmental factors and genetic susceptibilit...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2010-0747
更新日期:2010-01-01 00:00:00
abstract::Extra-nodal natural killer T-Cell (NK/T-cell) lymphoma is a progressive cancer with poor prognosis due to the lack of disease specific treatment. To develop specific therapeutic strategies, it is essential to identify tumor markers. Recent studies show that circulating microRNA (miRNA) may serve as diagnostic and/or p...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0755
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Amongst the genitourinary cancers, carcinoma of the urinary bladder is one of the leading causes of death in India. Hypermethylation of the CpG islands of gene promoter is one of the earliest and most frequent epigenetic alterations leading to cancer as well as in its development. Several studies have sugg...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0716
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Stroke subtype diagnosis leads to specific therapies to reduce recurrences. Because nearly one third of patients remain with unknown etiology after a complete screening workup, we aim to investigate whether molecular markers of myocardial damage were associated with cardioembolic stroke and if they were usef...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0630
更新日期:2009-01-01 00:00:00
abstract::Traditional lipid measures are the cornerstone of risk assessment and treatment goals in cardiovascular prevention. Whereas the association between total, LDL-, HDL-cholesterol and cardiovascular disease risk has been generally acknowledged, the rather poor capacity to distinguish between patients who will and those w...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2009-0636
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Tissue Polypeptide Specific antigen has recently been proposed as diagnostic marker of apoptosis in NonAlcoholic SteatoHepatitis. The aim of this study was to validate in patients suffering from NonAlcoholic SteatoHepatitis the clinical utility of this marker after different programs of weight reduction. ME...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0607
更新日期:2009-01-01 00:00:00
abstract::The total plasma concentration of homocysteine is a marker of this amino acid's atherogenic potential. However, the homocysteine pool exists almost entirely as oxidized homocysteine equivalents (OHcyE), composed of homocystine and cysteine-homocysteine disulphides (20-30%), and protein-bound disulphide (70-80%). We ha...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2009-0649
更新日期:2009-01-01 00:00:00